| | E 450 4MATIC | AMG E 63 S |
| Body | |
| Sunroof/Moonroof | Std |
| Rear Tailgate - Powered | Std |
| Exterior | |
| Side Mirrors - Power | Std |
| Lighting | |
| Headlamp Type | LED |
| Brakes | |
| ABS | Std |
| Stability Control | Std |
| Wheels / Tires | |
| Wheel Type | Alloy |
| Tire Size F (,R) | 245/45R18 | 265/35R20, 295/30R20 |
| Seating | |
| Seat Material | Leatherette | Leather |
| Power Adjustable Seats - 1st Row Driver Side | Std |
| Power Adjustable Seats - 1st Row Passenger Side | Std |
| Heated Seats - 1st Row | Opt | Std |
| HVAC | |
| Air Conditioning | Std |
| Climate Control Zones | 2 |
| Automatic Climate Control | Std |
| Driving Aids | |
| Cruise Control | Std |
| Infotainment | |
| Apple CarPlay | Std |
| Android Auto | Std |
| Navigation System | Std |
| Convenience | |
| Power Windows | Std |
| Power Door Locks | Std |
| Remote Lock/Unlock | Std |
